HCID 15557299, compound → HCID 15557348, compound

HRID 267771Notes

Reaction equation

HRID 267771 reaction equation
[ClH:1].O[C:3]1(CN)[CH2:9]OC2C=CC=CC=2O[CH2:4]1.Cl.[OH:17][C:18]1([CH:29]([NH2:31])[CH3:30])[CH2:24][O:23][C:22]2[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=2[O:20][CH2:19]1>>[ClH:1].[OH:17][C:18]1([CH:29]([NH:31][CH:3]([CH3:9])[CH3:4])[CH3:30])[CH2:19][O:20][C:21]2[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=2[O:23][CH2:24]1

Participants

3

Reactant 2

HCID 15557299HCID 15557299, compoundHCID 21553973HCID 21553973, compound

Product 1

HCID 15557348HCID 15557348, compound

Procedure

By replacing the 3-hydroxy-3-aminomethyl-3,4-dihydro-2H-1,5-benzodioxepin hydrochloride employed in Step F of Example 1 by an equivalent quantity of 3-hydroxy-3-(1-aminoethyl)-3,4-dihydro-2H-1,5-benzodioxepin hydrochloride and employing the same reaction conditions called for in Example 1, Step F, there is obtained 3-hydroxy-3-(1-isopropylaminoethyl)-3,4-dihydro-2H-1,5-benzodioxepin hydrochloride, M.P. 206°-211° C. It was purified by recrystallization from ethanol giving a product of M.P. 215°-7° .

Workup

  1. customthe same reaction conditions

Sources & evidence

ORD record
ord-61da21ddadde43a2b415fd3450290989
Source dataset
uspto-grants-1976_03
Patent number
US03944560

Reaction notes

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