Methanol → HCID 68135350, compound

Participants

Reaction Steps

4.0 g. of 17α-acetoxy-3,20-dioxo-4-pregnen-21-al is agitated at room temperature for 5 minutes in 100 ml. of N-methylpyrrolidone with 32 ml. of methanol, 6.4 ml. of concentrated acetic acid, 12 g. of manganese(IV) oxide, and 1.4 g. of potassium cyanide. The reaction product is then isolated as set forth in Example 39(b). After recrystallization from acetone-petroleum ether, 1.98 g. of the methyl ester of 17α-acetoxy-3,20-dioxo-4-pregnene-21-oic acid is obtained, m.p. 190.3°.

Provenance & Evidence