Sodium borohydride → HCID 21554236, compound

Participants

Reaction Steps

A solution of 49 g of this ketone in 100 ml of methanol is stirred dropwise into a solution, cooled to 0° C, of 11 g of sodium borohydride in 500 ml of methanol and 100 ml of water. The reaction solution is stirred for another hour and a half at 5° to 10° C and then allowed to stand at room temperature for 16 hours. Finally, 600 ml of water are added and the batch is extracted with methylene chloride, dried over sodium sulfate and evaporated. In this manner, 1-hydroxy-1-[para-(1-cycloheptenyl)-phenyl]-ethane is obtained as an oily, colorless residue.

Provenance & Evidence