Sodium borohydride → HCID 21554200, compound

Participants

Reaction Steps

8.8 g of para-(4-methyl-1-cyclohexenyl)-acetophenone are stirred portionwise into a solution, cooled to 0°C, of 1.8 g of sodium borohydride in 80 ml of methanol and 15 ml of water. Stirring is continued at 5°-10°C for an hour and a half and at room temperature for 4 hours, 200 ml of water are added, and the batch then extracted with 3 × 100 ml of methylene chloride. The methylene chloride residue is recrystallized from petroleum ether and yields 1-hydroxy-1-[para-(4-methyl-1-cyclohexenyl)-phenyl]-ethane of melting point 65°-67°C.

Provenance & Evidence