Sodium borohydride → HCID 21554190, compound

Participants

Reaction Steps

A solution of 7 g of sodium borohydride in 300 ml of methanol and 80 ml of water is cooled to 5°C and 50 g of p-(1-cyclohexenyl)-acetophenone are stirred in portionwise. The batch is stirred on for 2 hours at room temperature, the solution is concentrated to half its volume in a rotary evaporator, mixed with 1 litre of water and extracted with 3 × 500 ml of methylenechloride. The methylenechloride residue is recrystallized from petroleum ether and furnishes 1-hydroxy-1-[p-(1-cyclohexenyl)-phenyl]-ethane melting at 60°-62°C.

Provenance & Evidence