反应详情

温度

90 °C

A mixture of 42 g. (0.20 mole) of 3-dimethylamino-4'-fluoro-2-methylpropiophenone and 100 ml. of concentrated sulfuric acid is warmed to 90°C over one hour and stirred at 90°C for two hours. The reaction is cooled and quenched in ice and the product extracted into toluene. The toluene layer is washed with aqueous sodium hydroxide and water and concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

1. additionA mixture of 42 g
2. temperatureThe reaction is cooled
3. customquenched in ice
4. extractionthe product extracted into toluene
5. washThe toluene layer is washed with aqueous sodium hydroxide and water
6. concentrationconcentrated in vacuo