反应详情

Into a 250 ml. 3-necked flask fitted with a stirrer, dry ice-acetone trap, a gas outlet, and a gas inlet is charged 41.05 g. (1.0 mole) acetonitrile, 25 g. (0.25 mole) CaCO3, 13.5 ml. (0.75 mole) water and 26.8 g. (0.475 mole) 1-butene. The mixture is cooled to -5° to -8° C. and chlorine added over 2 hours maintaining the temperature at below 7° C. until the reaction mixture turns yellow indicating a slight excess of chlorine. The mixture is filtered and the solvents distilled under reduced pressure to yield 28.6 g. of N-[1-(chloromethyl)propyl]acetamide (40.2% yield bases on 1-butene).

1. custom3-necked flask fitted with a stirrer, dry ice-acetone trap, a gas outlet, and a gas inlet
2. additionis charged 41.05 g
3. temperatureThe mixture is cooled to -5° to -8° C.
4. temperaturemaintaining the temperature at below 7° C. until the reaction mixture
5. filtrationThe mixture is filtered
6. distillationthe solvents distilled under reduced pressure
7. customto yield 28.6 g