反应详情

3-Hydroxypyridazine-4-carboxylic acid (1.40 g) was dissolved in pyridine (20 ml) at 40°C, and p-nitrophenyl trifluoroacetate (2.82 g) was dropwise added thereto. The resultant mixture was stirred at 40° to 50°C for 1 hour and concentrated under reduced pressure to dryness. The residue was washed with chloroform and acetone in order and dried to give the objective compound (2.21 g). M.P. 233°C (decomp.).

1. concentrationconcentrated under reduced pressure to dryness
2. washThe residue was washed with chloroform and acetone in order
3. customdried