Water → HCID 21552765, compound

HRID 267902Notes

Reaction equation

HRID 267902 reaction equation
CC1[O:3][CH2:4][C:5]([CH3:16])([CH2:7][O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:6]=1.[OH-].[K+].O>C(O)C>[NH2:6][C:5]([CH3:16])([CH2:7][O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:4][OH:3]

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 21552767HCID 21552767, compound

Product 1

HCID 21552765HCID 21552765, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2,4-Dimethyl-4-benzyloxymethyloxazoline (80 grams, prepared by a similar method to that described in Example 1) and potassium hydroxide (100 grams) in aqueous ethanol were heated together under reflux for 4 days. The volume of the reaction mixture was reduced under reduced pressure and water (300 milliliters) was then added. The aqueous mixture was extracted with ether (3 × 250 milliliters) and the extracts dried and the solvent removed under reduced pressure. The residue was distilled under reduced pressure to give 2-amino-3-benzyloxy-2-methylpropanol as a colorless liquid, boiling point 128°-129°C at 1.1 Torr.

Workup

  1. temperaturewere heated together
  2. temperatureunder reflux for 4 days
  3. additionwas then added
  4. extractionThe aqueous mixture was extracted with ether (3 × 250 milliliters)
  5. customthe extracts dried
  6. customthe solvent removed under reduced pressure
  7. distillationThe residue was distilled under reduced pressure

Sources & evidence

ORD record
ord-40324db0184f498c96b206bd76730969
Source dataset
uspto-grants-1976_03
Patent number
US03945998

Reaction notes

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