4-Nitrobenzoic Acid → HCID 21552766, compound

Participants

Reaction Steps

2-Amino-3-benzyloxy-2-methylpropanol (13.5 grams) and 4-nitrobenzoic acid (11.7 grams) in dry xylene (100 milliliters) were heated together under reflux for 24 hours using a Dean-Stark trap for collection of the water formed during the reaction. The cooled solution was evaporated to dryness under reduced pressure and the residue was treated with ether and allowed to stand for 15 hours at 0°C. The yellow solid formed was recrystallized from ethanol to yield the desired product, melting point 65°-66°C.

Provenance & Evidence