Phosphorus oxychloride → 2-Chloro-3-(4-methoxyphenyl)pyrazine

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Reaction Steps

The 2-hydroxy-3-p-methoxyphenylpyrazine is refluxed (120°-130°C) with excess phosphorus oxychloride under stirring for 3-5 hours. The solution is evaporated to dryness at 50°C in vacuo, cooled, ice is added, then treated with 10% sodium hydroxide solution, extracted with a suitable solvent such as diethyl ether, the ethereal solution washed with water and evaporated. The crude product is crystallized from a suitable solvent such as ethanol to give 2-chloro-3-p-methoxyphenylpyrazine.

Provenance & Evidence