HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-Chloro-3-methoxypyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2,3-Dichloropyrazine | HCID 78575 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Chloro-3-methoxypyrazine | HCID 11804891 | — |
Reaction Steps
A mixture of 0.1 mole of 2,3-dichloropyrazine and 2.3 g. (0.1 mole) of sodium in 160 ml. of anhydrous methanol is refluxed 5-10 hours, and poured into water. The product is extracted with ether or chloroform and recrystallized from a suitable solvent such as ethanol to give pure 2-chloro-3-methoxypyrazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03946009 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-328b8ba09a9b4a25963b9f46fd604e5f |
| Source note | uspto-grants-1976_03 |