HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 14450325, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Reactant | 8-Methoxy-1,2,3,4-tetrahydro-chromeno[3,4-c]pyridin-5-one | HCID 13136918 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 14450325 | HCID 14450325 | — |
Reaction Steps
A mixture of 10 g (0.043 m) of 1,2,3,4-tetrahydro-8-methoxy-5H-[1]benzopyrano [3,4-c]pyridin-5-one, 11.2 g (0.06 m) of N-(2-chloroethyl)morpholine HCl and 14.2 g of triethylamine (0.14 m) in 170 ml of abs. EtOH was refluxed with stirring and protection from moisture for 4 hours. The reaction was filtered hot, cooled slightly and treated with dry HCl. The resulting precipitate was filtered and washed with EtOH, then ether; yield 14.6 g (81%). Crystallization from methanol afforded analytical material, mp 237°-40° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03946008 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-826280f0a13642a392582e6fe2caeac0 |
| Source note | uspto-grants-1976_03 |