1-(2-Chloroethyl)piperidine → HCID 21447166, compound

HRID 267960Notes

Reaction equation

HRID 267960 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]2[C:11]3[CH2:16][CH2:15][NH:14][CH2:13][C:12]=3[C:17](=[O:19])[O:18][C:5]=2[CH:4]=1.Cl[CH2:21][CH2:22][N:23]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]2[C:11]3[CH2:16][CH2:15][N:14]([CH2:21][CH2:22][N:23]4[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]4)[CH2:13][C:12]=3[C:17](=[O:19])[O:18][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 748271-(2-Chloroethyl)piperidineHCID 21447169HCID 21447169, compound

Product 1

HCID 21447166HCID 21447166, compound

Procedure

In the same way as described in Example 5, 0.02 m of 1,2,3,4-tetrahydro-8,10-dimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one was alkylated with N-(2-chloroethyl)-piperidine to give, after crystallization from MeOH, 3.0 g of product; mp 190°-224° C.

Workup

  1. customto give
  2. customafter crystallization from MeOH, 3.0 g of product

Sources & evidence

ORD record
ord-d3b605d12fb845ec900ed132dd8e61dd
Source dataset
uspto-grants-1976_03
Patent number
US03946008

Reaction notes

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