HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 8,9-Diethoxy-1,2,3,4-tetrahydro-3-(2-morpholinoethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Diethyl Sulfate | HCID 6163 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,2,3,4-tetrahydro-8,9-dihydroxy-3-(2-morpholinoethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one | HCID 21447167 | — |
| Product | 8,9-Diethoxy-1,2,3,4-tetrahydro-3-(2-morpholinoethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one | HCID 21447168 | — |
Reaction Steps
A mixture of 0.01 m of 1,2,3,4-tetrahydro-8,9-dihydroxy-3-(2-morpholinoethyl)-5H-[1]benzopyrano[3,4-c]pyridin-5-one, 0.022 m of diethylsulfate, and 0.1 m of K2CO3 in 500 ml of acetone was refluxed for 18 hr, filtered hot and evaporated. Residue was dissolved in CHCl3 and washed with 3% NaOH soln. CHCl3 soluble material was crystallized from MeOH containing an excess of HCl gas affording 1 g of product; mp 240°-260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03946008 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-421c4de91718406dae330fdcc5924a89 |
| Source note | uspto-grants-1976_03 |