HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 5-[4-(alpha-Hydroxy-alpha-phenylbenzyl)piperidino]valerophenone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Azacyclonol | HCID 15723 | — |
| Reactant | 5-Chloro-1-phenyl-1-pentanone | HCID 70338 | — |
| Reactant | Potassium Bicarbonate | HCID 516893 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-[4-(alpha-Hydroxy-alpha-phenylbenzyl)piperidino]valerophenone hydrochloride | HCID 21552998 | — |
Reaction Steps
A mixture of 27.6 g (0.1 mole) of α,α-diphenyl-4-piperidinemethanol, 21.6 g (0.11 mole) of 5-chlorovalerophenone, 20 g of potassium bicarbonate, and 0.1 g of potassium iodide in 300 ml of toluene and 25 ml of water is stirred and refluxed for 136 hours then worked up by the procedure described in Examples 2 and 3 to give 5-[4-(α-hydroxy-α-phenylbenzyl)piperidino]valerophenone hydrochloride, M.P. 162°-164°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03946022 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-ecdb1a75e63c4c2685b929b1aa626727 |
| Source note | uspto-grants-1976_03 |