Potassium Hydroxide → HCID 21552967, compound

Participants

Reaction Steps

To 62.3 g (0.12 mole) of 4'-tert-butyl-5-[4-(α-hydroxy-α-phenylbenzyl)piperidino]valerophenone hydrochloride dissolved in about 1200 ml of methanol is added methanolic potassium hydroxide until the solution is basic. The solution is cooled in an ice bath with stirring and 5 g (0.13 mole) of sodium borohydride is added portionwise. The mixture is stirred an additional half hour, allowed to warm to room temperature then heated on a steam bath for half an hour. The solvent is removed at reduced pressure and the remaining residue is washed with water and recrystallized from acetone to give α-(p-tert-butylphenyl)-4-(α-hydroxy-α-phenylbenzyl)-1-piperidine-pentanol.

Provenance & Evidence