Hydroxyamine hydrochloride → HCID 86733172, compound

Participants

Reaction Steps

A mixture of 15 g (0.028 mole) of 4'-tert-butyl-5-[4-(α-hydroxy-α-phenylbenzyl)piperidino]valerophenone hydrochloride and 15 g of hydroxylamine hydrochloride in 120 ml of pyridine in heated on a steam bath for about 5 hours after which the pyridine is removed at reduced pressure. The remaining residue is dissolved in methanol and added to excess iced 10% HCl. The resulting solid is filtered, washed with water, and recrystallized from isopropyl alcohol to give 4'-tert-butyl-5-[4-(α-hydroxy-α-phenylbenzyl)piperidino]valerophenone oxime hydrochloride.

Provenance & Evidence