Potassium Iodide → 5-[4-(alpha-Hydroxy-alpha-phenylbenzyl)piperidino]-4'-piperidinovalerophenone

Participants

Reaction Steps

A mixture of 15.6 g (0.35 mole) of 4'-fluoro-5-[4-(α-hydroxy-α-phenylbenzyl)piperidino]valerophenone, the free base of the compound of Example 2, and a small amount of potassium iodide in 100 ml of piperidine is refluxed for about 22 hours. The unreacted piperidine is removed under vacuum, and the remaining residue is triturated with water. The water is decanted and the residue is dissolved in methanol and then added to a large amount of water. The resulting precipitate is dissolved in a large volume of ether, dried over magnesium sulfate, and filtered. The filtrate is concentrated and cooled yielding a product which is recrystallized from ether to give 5-[4-(α-hydroxy-α-phenylbenzyl)piperidino]-4'-piperidinovalerophenone.

Provenance & Evidence