反应详情

A solution of aminooxyacetic acid hemihydrochloride (60.0 g.) in water (180 cc.) is added to a stirred boiling solution of 7H-indolizino 5,6,7-ij]isoquinolin-7-one (60.0 g.) in ethanol (1,800 cc.) and pyridine (27.3 cc.). Boiling is maintained for 2 hours 30 minutes. After cooling, the yellow crystals obtained are filtered off, washed with 90% ethanol, then with absolute ethanol and finally with diethyl ether. After drying, 7-carboxymethoxyimino-7H-indolizino[5,6,7-ij]isoquinoline (67.6 g.), melting at 212° C. with decomposition, is obtained.

1. temperatureBoiling is maintained for 2 hours 30 minutes
2. temperatureAfter cooling
3. customthe yellow crystals obtained
4. filtrationare filtered off
5. washwashed with 90% ethanol
6. customAfter drying