反应详情

A solution of 2-aminooxypropionic acid hydrochloride (15.0 g.) in water (37.5 cc.) is added to a stirred boiling solution of 7H-indolizino[5,6,7-ij]isoquinolin- 7-one (15.0 g.) in ethanol (375 cc.) and pyridine (8.14 g.). Boiling is maintained for 2 hours 30 minutes. After cooling, the orange crystals are filtered off, washed with 90% ethanol, then with absolute ethanol and finally with diethyl ether. After drying, 7-(1-carboxyethoxyimino)-7H-indolizino[5,6,7-ij]isoquinoline (16.0 g.), melting at 225° C. with decomposition, is obtained.

1. temperatureBoiling is maintained for 2 hours 30 minutes
2. temperatureAfter cooling
3. filtrationthe orange crystals are filtered off
4. washwashed with 90% ethanol
5. customAfter drying