反应详情

A solution of 3-aminooxypropionic acid hydrochloride (12 g.) in water (36 cc.) is added to a stirred boiling solution of 7H-indolizino[5,6,7-ij]isoquinolin-7-one (12 g.) in ethanol (360 cc.) and pyridine (6.64 g.). Boiling is maintained for 3 hours 10 minutes. After cooling, the yellow crystals obtained are filtered off and then washed with 90% ethanol, with absolute ethanol and finally with diethyl ether. After drying, 7-(2-carboxyethoxyimino)-7H-indolizino[5,6,7-ij]isoquinoline (12.59 g.), melting at 250° C. with decomposition, is obtained.

1. temperatureBoiling is maintained for 3 hours 10 minutes
2. temperatureAfter cooling
3. customthe yellow crystals obtained
4. filtrationare filtered off
5. washwashed with 90% ethanol, with absolute ethanol and finally with diethyl ether
6. customAfter drying