反应详情

温度

10 °C

Acetic anhydride (20 cc.) is added, over the course of 5 minutes, to a stirred suspension of 7-hydroxyimino-7H-indolizino[5,6,7-ij]isoquinoline (10 g.) in pyridine (100 cc.) kept at between 8° and 10° C. A brown solution is thus obtained. After stirring for 5 minutes at 10° C., the acetic acid ester crystallises. The mixture is kept at ambient temperature for a further 2 hours and then water (600 cc.) is added. The ochre-yellow crystals thus obtained are filtered off and washed copiously with water. After drying, 7-acetyloxyimino-7H-indolizino[5,6,7-ij]isoquinoline (11.0 g.), melting at 177°-179° C. with decomposition, is obtained.

1. customkept at between 8° and 10° C
2. customA brown solution is thus obtained
3. customthe acetic acid ester crystallises
4. waitThe mixture is kept at ambient temperature for a further 2 hours
5. additionwater (600 cc.) is added
6. customThe ochre-yellow crystals thus obtained
7. filtrationare filtered off
8. washwashed copiously with water
9. customAfter drying