HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Naphthaldehyde → 2-Methyl-4-(alpha-naphthyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Naphthaldehyde | HCID 6195 | — |
| Reactant | Diethyl oxalacetate | HCID 66951 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Methyl-4-(alpha-naphthyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester | HCID 68134230 | 65% |
Reaction Steps
After heating a solution of 15.6 g of 1-naphthaldehyde, 19 g of oxalacetic acid diethyl ester and 13 g of β-aminocrotonic acid ethyl ester in 40 ccs of ethanol under reflux for 6-8 hours, and cooling, light yellow crystals of melting point 112° (ethanol) are obtained. Yield 65%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03946027 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-2d7a33dfe0ec451e83a490e47c79bbe0 |
| Source note | uspto-grants-1976_03 |