HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl oxalacetate → Diethyl oxalacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl oxalacetate | HCID 66951 | — |
| Reactant | 4-(Methylthio)benzaldehyde | HCID 76985 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Diethyl oxalacetate | HCID 66951 | — |
| Product | 4-(Methylthio)benzaldehyde | HCID 76985 | — |
| Product | Methyl 3-aminocrotonate | HCID 643918 | — |
Reaction Steps
A solution of 7.6 g of 4-methylmercaptobenzaldehyde, 9.5 g of oxalacetic acid diethyl ester and 6.5 g of β-aminocrotonic acid ethyl ester in 40 ccs of ethanol is heated to the boil overnight and evaporated in vacuo. Oil (orange). a. In the same way, 2-methyl-4-(4'-methylmercaptophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester-5,6-dicarboxylic acid diethyl ester is obtained from 7.6 g of 4-methylmercaptobenzaldehyde, 9.5 g of oxalacetic acid diethyl ester and 5.8 g of β-aminocrotonic acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03946027 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-c16c3b9ee4404985933d8eea99aa6006 |
| Source note | uspto-grants-1976_03 |