HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitrobenzaldehyde → 4-(2'-Nitrophenyl)-1,4-dihydropyridine-2,3,5,6-tetracarboxylic acid tetraethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitrobenzaldehyde | HCID 11101 | — |
| Reactant | Diethyl oxalacetate | HCID 66951 | — |
| Reactant | Diethyl 2-iminobutanedioate | HCID 18977200 | — |
| Product | 4-(2'-Nitrophenyl)-1,4-dihydropyridine-2,3,5,6-tetracarboxylic acid tetraethyl ester | HCID 86733113 | 58% |
Reaction Steps
A solution of 7.5 g of o-nitrobenzaldehyde, 9.5 g of oxalacetic acid diethyl ester and 9.4 g of iminosuccinic acid diethyl ester in 30 ccs of alcohol is heated under reflux overnight and subsequently cooled. After filtration, light yellow crystals of melting point 109° (ethanol) are obtained. Yield 58%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03946028 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-3680e353e42f405f998d1904ed6b4bdd |
| Source note | uspto-grants-1976_03 |