HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4,5-Trimethoxybenzaldehyde → 2-Methyl-4-(3',4',5'-trimethoxyphenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4,5-Trimethoxybenzaldehyde | HCID 6858 | — |
| Reactant | Diethyl oxalacetate | HCID 66951 | — |
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-Methyl-4-(3',4',5'-trimethoxyphenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethyl ester | HCID 68133689 | 40% |
Reaction Steps
11.8 g of 3,4,5-trimethoxybenzaldehyde, 14 g of oxalacetic acid diethyl ester and 7.8 g of β-aminocrotonic acid ethyl ester in 30 ccs of ethanol are heated to the boil overnight and light yellow crystals of melting point 134° are obtained. Yield 40%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03946028 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-a4384c7fd5dd4ea2ad34bc8565005eb5 |
| Source note | uspto-grants-1976_03 |