HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Diethoxyacetohydrazide → 6-(o-fluorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde-diethylacetal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Diethoxyacetohydrazide | HCID 10855786 | — |
| Reactant | 7-chloro-5-(2-fluorophenyl)-2-methylthio-3H-1,4-benzodiazepine | HCID 15499283 | — |
| Solvent | Hexamethylphosphoramide | HCID 12679 | — |
| Product | 6-(o-fluorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde-diethylacetal | HCID 21553110 | — |
Reaction Steps
A solution of 15.9 g of 2-(methylthio)-5-(o-fluorophenyl)-7-chloro-3H-1,4-benzodiazepine and 9.7 g of diethoxyacetic acid hydrazide in 100 ml of hexamethylphosphoric acid triamide is heated for 10 hours at 140°; processing is then carried out analogously to the procedure described in Example 1, and the residue recrystallised from ethyl acetate/petroleum ether to obtain 6-(o-fluorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde-diethylacetal, M.P. 120°-121°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03946032 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-068905ecf3324a1f98ad5ecd2efd92ab |
| Source note | uspto-grants-1976_03 |