反应详情

70 g G 4-mercapto-phenyl-acetic acid are heated at reflux for 30 minutes in 500 cc of 4 N hydrochloric acid in ethanol. The reaction mixture is then completely concentrated at reduced pressure. The oily residue is divided between ether and water, the ether phase is subsequently washed with a 10% sodium bicarbonate solution and water, is dried over sodium sulphate, and the solvent is removed by distillation. The crude 4-mercapto-phenyl-acetic acid ethyl ester, obtained as oily residue, may be purified by distillation; B.P. 103° at 0.4 mm of Hg.

1. concentrationThe reaction mixture is then completely concentrated at reduced pressure
2. washthe ether phase is subsequently washed with a 10% sodium bicarbonate solution and water
3. dry with materialis dried over sodium sulphate
4. customthe solvent is removed by distillation