Carbamimidoyl-acetic acid ethyl ester → HCID 70634641, compound

HRID 268075Notes

Reaction equation

HRID 268075 reaction equation
C(O[C:4](=O)[CH2:5][C:6]([CH:8]=[CH:9][C:10]1[S:14][CH:13]=[CH:12][CH:11]=1)=O)C.[CH2:16]([O:18][C:19](=[O:24])[CH2:20][C:21](=[NH:23])[NH2:22])[CH3:17]>C(O)C>[CH2:16]([O:18][C:19]([C:20]1[CH:8]([CH2:9][C:10]2[S:14][CH:13]=[CH:12][CH:11]=2)[C:6]([C:19]([O:18][CH2:16][CH3:17])=[O:24])=[C:5]([CH3:4])[NH:23][C:21]=1[NH2:22])=[O:24])[CH3:17]

Participants

4

Reactant 2

HCID 4599837Carbamimidoyl-acetic acid ethyl esterHCID 53707123HCID 53707123, compound

Product 1

HCID 70634641HCID 70634641, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Upon heating a solution of 12.2 g of (2-thenylidene) acetoacetic acid ethyl ester and 6.5 g of amidinoacetic acid ethyl ester in 100 ml of ethanol for 4 hours, 2-amino-6-methyl-4-(2-thenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of melting point 170°C (ethanol) is obtained.

Sources & evidence

ORD record
ord-dc85b588e5404dc1ad78b2ebcb4b99ec
Source dataset
uspto-grants-1976_03
Patent number
US03946026

Reaction notes

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