HCID 54087479, compound → HCID 54255059, compound

Participants

Reaction Steps

A mixture of 55 g (0.19 mole) of the compound of Example II, 500 ml of CH3OH and one teaspoon of 5% Pd/C (50% H2O) was shaken on the Parr apparatus with the theoretical amount of H2 being absorbed. The catalyst was removed by filtration and the solvent removed on the Calab evaporator leaving a residual solid which was washed in refluxing acetonitrile. The resulting solid was then washed in 1 N NaOH solution and air dried to yield 22 g (52%). An analytical sample was prepared by drying a sample at the temperature of refluxing CHCl3 in the vacuum pistol, m.p. 180°-183°.

Provenance & Evidence