Acetic Anhydride → HCID 12227147, compound

HRID 268098Notes

Reaction equation

HRID 268098 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][C:12]([CH:14]=[N:15]O)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.C(OC(=O)C)(=O)C>CCOCC>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:13][C:12]([C:14]#[N:15])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 85436872HCID 85436872, compound

Product 1

HCID 12227147HCID 12227147, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A 500 ml three-necked flask equipped with stirrer, thermometer and reflux condenser was charged with 5-(p-methoxyphenyl)-2-furaldehyde oxime (28 g, 0.129 mole) and acetic anhydride (317 ml). This mixture was refluxed (138°) for 3 hours. After cooling to room temperature overnight, the green solution was poured into ice water (ca. 2l. ) with stirring. When the ice melted, the solid was collected by filtration, washed with water, and dried to give 26 g.

Workup

  1. customA 500 ml three-necked flask equipped with stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureThis mixture was refluxed (138°) for 3 hours
  4. filtrationthe solid was collected by filtration
  5. washwashed with water
  6. customdried
  7. customto give 26 g

Sources & evidence

ORD record
ord-5326d26079af4b7ca96f8d30b084d4bc
Source dataset
uspto-grants-1976_03
Patent number
US03946049

Reaction notes

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