Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tyramine | HCID 5610 | — |
| Reactant | Triethylammonium hydrogen carbonate | HCID 11768884 | — |
| Reactant | n-Hydroxysuccinimide biotin | HCID 86743017 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Biotin tyramine | HCID 86746652 | — |
Reaction Steps
a solution of biotin-N-hydroxysuccinimide, 170 mg (0.5 mMoles), and tyramine (recrystallized from water), 68.5 mg (0.5 mMoles), in 25 ml dimethylformamide was treated with 10 ml of 1M triethylammonium bicarbonate, pH 7.5, and then heated at 50° C. for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05731158 |
|---|
| Source dataset | uspto-grants-1998_03 |
|---|
| ORD ID | ord-989c68d91dfc4d74a9b62cfdff0165f9 |
|---|
| Source note | uspto-grants-1998_03 |
|---|
