Water → 2-(5-Phenyl-1,3,4-thiadiazol-2-yl)benzoic acid

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Reaction Steps

2-o-Methylphenyl-5-phenyl-1,3,4-thiadiazole (25 g.) was suspended in a solution of potassium permanganate (40 g.) in water (475 ml.). The reaction mixture was stirred and refluxed until the color of permanganate had discharged, then filtered and cooled. Unreacted 2-o-methylphenyl-5-phenyl-1,3,4-thiadiazole which separated was removed by filtration. When this filtrate was acidified, 2-(5-phenyl-1,3,4-thiadiazol-2-yl)benzoic acid was obtained and recrystallized from ethanol to give white crystals, M.P. 178°-180°. Analysis gave C, 63.37; H, 3.74; N, 9.74. C15H10N2O2S requires C, 63.83; H, 3.51; N, 9.93.

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