Acetaldehyde → 3,3,5-Trimethylcyclohexanone

Participants

Reaction Steps

1-Amino-3,3,5-trimethylcyclohexyl hydroperoxide (17.3 g; 78% pure) was added with stirring to acetaldehyde (12 g.) in light petroleum (b.p. 40° - 60°C) 50 c.c.) with cooling to below 0°C. When the hydroperoxide had dissolved, the organic layer was separated, treated with solid magnesium sulphate and stored at 0°C overnight. The solution was then filtered, washed and distilled as in Example 1 and gave, in addition to dihydroisophorone, the same product (13.0 g.) as Example 1.

Provenance & Evidence