Sodium Hydroxide → HCID 21551641, compound

Participants

Reaction Steps

3.8 g of 2,4-bis-[(tetrahydropyran-2-yloxy)-amino]-5-(3,4,5-trimethoxybenzyl)-pyrimidine is stirred in 30 ml of 1N hydrochloric acid for 10 minutes at room temperature. The reaction mixture is then neutralised with 1N sodium hydroxide solution and the precipitating oil is taken up in methylene chloride. Chromatography on silica gel with the use of methylene chloride as eluant yields 2-[(tetrahydropyran-2-yloxy)-amino]-4-(hydroxyamino)-5-(3,4,5-trimethoxybenzyl)-pyrimidine, M.P. 190°-192°.

Provenance & Evidence