Ethanolamine → HCID 13255893, compound

Participants

Reaction Steps

To a stirred solution of 3.76 parts of 1-(2-benzoyl-4-chlorophenyl)-5-chloromethyl-1H-1,2,4-triazole-3-carboxylic acid and 1.4 volume part of triethylamine in 60 volume parts of dry tetrahydrofuran, 1.0 volume part of ethyl chlorocarbonate is added dropwise under cooling with ice-salt. After 5 minutes, a solution of 1.2 volume part of ethanolamine in 10 volume parts of dry tetrahydrofuran is added dropwise to the mixture. After evaporation of the solvent below 40°C under reduced pressure, the residue is diluted with water. This procedure yields 1-(2-benzoyl-4-chlorophenyl)-5-chloromethyl-N-(2-hydroxyethyl)-1H-1,2,4-triazole-3-carboxamide as crystals. Recrystallization from ethanol gives colorless prisms melting at 170°-171°C.

Provenance & Evidence