Phosphorus trichloride → HCID 21551706, compound

Participants

Reaction Steps

20 g (0.066 mole) of 7-chloro-3,3-dimethyl-10-hydroxy-1-oxo-1,2,3,4-tetrahydro-9(10H)-acridone were suspended in 320 ml of chloroform and, after heating on a steam bath, combined dropwise with 11.3 ml (0.13 mole) of phosphorus trichloride. Upon cooling, 16 g of 7-chloro-3,3-dimethyl-1-oxo-1,2,3,4-tetrahydro-9(10H)-acridone crystallized in the form of the hydrochloride. This compound was dissolved in a mixture of 300 ml of methanol and 50 ml of binormal sodium hydroxide solution, the solution was filtered, the filtrate was concentrated under reduced pressure and the base that had crystallized was filtered off with suction. 13.5 g (74 % ) of 7-chloro-3,3-dimethyl-1-oxo-1,2,3,4-tetrahydro-9(10H)-acridone were obtained. Decomposition point 300° C.

Provenance & Evidence