2-(4-bromobutyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione → 1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride

HRID 268237Notes

Reaction equation

HRID 268237 reaction equation
[ClH:1].C1C2C(=CC=CC=2)CCN1CCCC[N:16]1[C:25](=[O:26])[C:24]2[CH:27]=[CH:28][CH:29]=[C:22]3[C:23]=2[C:18](=[CH:19][CH:20]=[CH:21]3)[C:17]1=[O:30].BrCCCCCN1C(=O)C2C=CC=C3C=2C(=CC=C3)C1=O.BrCCCCN1C(=O)C2C=CC=C3C=2C(=CC=C3)C1=O>>[ClH:1].[C:17]1(=[O:30])[C:18]2[C:23]3[C:22](=[CH:29][CH:28]=[CH:27][C:24]=3[C:25](=[O:26])[NH:16]1)[CH:21]=[CH:20][CH:19]=2

Participants

4

Reactant 3

HCID 27823602-(4-bromobutyl)-1H-benzo[de]isoquinoline-1,3(2H)-dioneHCID 166387912-(5-Bromopentyl)benzo[de]isoquinoline-1,3-dioneHCID 1317101094-(3,4-Dihydro-2(1H)-isoquinolinyl)butyl-1H-benz[de]-isoquinoline-1,3(2H)-dione, hydrochloride

Product 1

HCID 693806221H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride

Procedure

Following the procedure of part (b) of example 39 but substituting 2-(5-bromopentyl)-1H-benz[de]isoquinoline-1,3(2H)-dione for the 2-(4-bromobutyl)-1H-benz[de]isoquinoline-1,3(2H)-dione, one obtains 2-[5-(3,4-dihydro)-2(1H)-isoquinolinyl)-pentyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride (1:1).

Sources & evidence

ORD record
ord-9970bc58fe624e1fa1a77060525c33cb
Source dataset
uspto-grants-1976_03
Patent number
US03947452

Reaction notes

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