2-(4-bromobutyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione → 2-[6-(3,4-dihydro-2(1H)-isoquinolinyl)-hexyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride

HRID 268239Notes

Reaction equation

HRID 268239 reaction equation
[ClH:1].C1C2C(=CC=CC=2)CCN1CC[CH2:14][CH2:15][N:16]1[C:25](=[O:26])[C:24]2[CH:27]=[CH:28][CH:29]=[C:22]3[C:23]=2[C:18](=[CH:19][CH:20]=[CH:21]3)[C:17]1=[O:30].BrCC[CH2:34][CH2:35][CH2:36][CH2:37][N:38]1[C:47](=O)[C:46]2C=CC=[C:44]3[C:45]=2[C:40](=[CH:41][CH:42]=[CH:43]3)[C:39]1=O.BrCCCCN1C(=O)C2C=CC=C3C=2C(=CC=C3)C1=O>>[ClH:1].[CH2:39]1[C:40]2[C:45](=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH2:46][CH2:47][N:38]1[CH2:37][CH2:36][CH2:35][CH2:34][CH2:14][CH2:15][N:16]1[C:25](=[O:26])[C:24]2[CH:27]=[CH:28][CH:29]=[C:22]3[C:23]=2[C:18](=[CH:19][CH:20]=[CH:21]3)[C:17]1=[O:30]

Participants

4

Reactant 3

HCID 27823602-(4-bromobutyl)-1H-benzo[de]isoquinoline-1,3(2H)-dioneHCID 203645072-(6-bromohexyl)-1H-benz[de]isoquinoline-1,3(2H)-dioneHCID 1317101094-(3,4-Dihydro-2(1H)-isoquinolinyl)butyl-1H-benz[de]-isoquinoline-1,3(2H)-dione, hydrochloride

Product 1

HCID 1317101102-[6-(3,4-dihydro-2(1H)-isoquinolinyl)-hexyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride

Procedure

Following the procedure of part (b) of example 39 but substituting 2-(6-bromohexyl)-1H-benz[de]isoquinoline-1,3(2H)-dione for the 2-(4-bromobutyl)-1H-benz[de]isoquinoline-1,3-(2H)-dione, one obtains 2-[6-(3,4-dihydro-2(1H)-isoquinolinyl)-hexyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, hydrochloride (1:1).

Sources & evidence

ORD record
ord-b6e32ed1d62040fbb60f99d9a8ce7ef3
Source dataset
uspto-grants-1976_03
Patent number
US03947452

Reaction notes

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