HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → N-[4-chloro-3-(trifluoromethyl)phenyl]-7-methyl-3H-imidazo[4,5-f]quinolin-9-amine;hydrate;hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4-Chloro-3-(trifluoromethyl)aniline | HCID 67574 | — |
| Reactant | HCID 178428198 | HCID 178428198 | — |
| Product | N-[4-chloro-3-(trifluoromethyl)phenyl]-7-methyl-3H-imidazo[4,5-f]quinolin-9-amine;hydrate;hydrochloride | HCID 178428211 | — |
Reaction Steps
A stirred mixture of the compound of Example I, C. (22 g. 0.1 mole) and 5-amino-2-chlorobenzotrifluoride (20 g. 0.1 mole) in 200 ml. of dimethylformamide, was refluxed for 6 hours. The reaction solution was stripped in vacuo to give 35 g. (82%) of tan product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03947434 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-d9d8167bb438416fbf6c6f47a8d247c5 |
| Source note | uspto-grants-1976_03 |