Hydrogen Bromide → HCID 68131887, compound

Participants

Reaction Steps

The free base prepared from 12.2 g. of rac.-4-(4-chlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methylisoquinoline hydrochloride is stirred at reflux with 150 ml. of 48% hydrobromic acid solution for 2 hours at a bath temperature of 160°. After evaporation and recrystallization from methanol-ether there is obtained rac.-4-(4-chlorophenyl)-1,2,3,4-tetrahydro-2-methyl-7-isoquinolinol hydrobromide of m.p. 292°-293°. The free base of this compound displays a m.p. of 189°-190° after recrystallization from ether, the hydrochloride after recrystallization from methanol-ether melts at 295°-297°.

Provenance & Evidence