Sulfuric Acid → HCID 68132289, compound

Participants

Reaction Steps

At room temperature with stirring, 7.12 g. of rac.-4-chloro-α-{[(3,4-dimethoxybenzyl)amino]methyl}benzyl alcohol hydrochloride are introduced into 100 ml. of a mixture of equal parts by volume of conc. sulfuric acid and water and heated of 80° for 30 minutes. After rendering alkaline, extraction of the base with methylene chloride, acidification with ethanolic hydrogen chloride and recrystallization from ethanol-ether there is obtained rac.-4-(4-chlorphenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline hydrochloride of m.p. 186°-187°. The free base displays a m.p. of 118°-119° after recrystallization from ether.

Provenance & Evidence