HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-amino-1-(4-nitrophenyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | p-Nitroacetophenone | HCID 7487 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-amino-1-(4-nitrophenyl)ethanol | HCID 2831405 | — |
Reaction Steps
4-Nitroacetophenone is brominated in the α-position, the product obtained is redcuced by means of sodium borohydride to the corresponding bromohydrin and this is treated with ammonia. Rac.-α-(aminomethyl)-4-nitrobenzyl alcohol, m.p. 138°-139° (from ethyl acetate) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03947456 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-f83b551be5734287b4269b3d4ba208bf |
| Source note | uspto-grants-1976_03 |