HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Amino-1-(3-nitrophenyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | m-Nitroacetophenone | HCID 8494 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Product | 2-Amino-1-(3-nitrophenyl)ethanol | HCID 18628156 | — |
Reaction Steps
3-Nitroacetophenone is brominated in the α-position, the bromination product is reduced by means of sodium borohydride to the corresponding bromohydride and this is treated with ammonia. There is obtained rac.-α-(aminomethyl)-3-nitrobenzyl alcohol which melts at 107°-108° (softening from 105°) after crystallization from ethyl acetate-ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03947456 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-43b11491cddd49dd992e9585706b5712 |
| Source note | uspto-grants-1976_03 |