Hydrogen Bromide → HCID 68132713, compound

Participants

Reaction Steps

The free base obtained from 4.0 g. of rac.-1,2,3,4-tetrahydro-7-methoxy-2-methyl-4-(3-nitrophenyl)isoquinoline hydrochloride is heated to 150°C. (bath-temperature) for 1.5 hours with 60 ml. of 48% hydrogen bromide solution. After concentration and partitioning between sodium bicarbonate solution and ethyl acetate, acidification with ethanolic hydrogen chloride, crystallization with ether and recrystallization from methanol-ether, there is obtained colorless rac.-1,2,3,4-tetrahydro-2-methyl-4-(3-nitrophenyl)-7-isoquinolinol hydrochloride of melting point 257°-258°C. (dec.).

Provenance & Evidence