Formaldehyde → HCID 68132266, compound

Participants

Reaction Steps

The free base released from 6.5 g. of rac.-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline hydrochloride is heated at 120°C. (bath temperature) for 1 hour with 10 ml. of formic acid and 10 ml. of 35% formalin solution. After evaporation, extraction with sodium carbonate solution and methylene chloride and acidification with ethanolic hydrogen chloride, there is obtained rac.-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline hydrochloride which is recrystallized from methanol-ether and then melts at 243°-246°C. (softening at 238°C). The free base melts at 115°-116°C. after recrystallization from ether-petroleum ether.

Provenance & Evidence