Hydrochloric Acid → HCID 88837870, compound

Participants

Reaction Conditions

Reaction Steps

In a 10 ml. reaction flask equipped with a reflux condenser, there are added 226 mg (0.93 mmol) of trans-methyl-3-(1.3-dithian-2-yl)-4-cyclopentene-2-carboxylate (as prepared in example 6) dissolved in 5 ml. of distilled water and a few mg of sodium hydroxide dissolved in one ml. of distilled water. The mixture is heated to 80° C for 3 hours, then cooled and neutralized by 5% HCl. The solution is extracted with ether and the ethereal layer is dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to yield trans-3-(1,3-dithian-2-yl)-4-cyclopentene-2-carboxylic acid.

Provenance & Evidence