p-Anisoyl chloride → 3-(4-Hydroxybenzoyl)-2-(4-tolyl)benzofuran

HRID 268362Notes

Reaction equation

HRID 268362 reaction equation
C1(C)C=CC(C2OC3C=CC=CC=3C=2)=CC=1.C(Cl)(=O)C1C=CC(OC)=CC=1.C[O:29][C:30]1[CH:53]=[CH:52][C:33]([C:34]([C:36]2[C:40]3[CH:41]=[CH:42][CH:43]=[CH:44][C:39]=3[O:38][C:37]=2[C:45]2[CH:50]=[CH:49][C:48]([CH3:51])=[CH:47][CH:46]=2)=[O:35])=[CH:32][CH:31]=1>>[OH:29][C:30]1[CH:31]=[CH:32][C:33]([C:34]([C:36]2[C:40]3[CH:41]=[CH:42][CH:43]=[CH:44][C:39]=3[O:38][C:37]=2[C:45]2[CH:46]=[CH:47][C:48]([CH3:51])=[CH:49][CH:50]=2)=[O:35])=[CH:52][CH:53]=1

Participants

4

Reactant 3

HCID 7477p-Anisoyl chlorideHCID 6384582-(p-Tolyl)benzofuranHCID 214352893-(4-Methoxybenzoyl)-2-(4-tolyl)benzofuran

Product 1

HCID 214352683-(4-Hydroxybenzoyl)-2-(4-tolyl)benzofuran

Procedure

3-(4-Hydroxybenzoyl)-2-(4-tolyl)benzofuran is prepared by acylation of 2-(4-tolyl)benzofuran with p-anisoyl chloride followed by demethylation of the 3-(4-methoxybenzoyl)-2-(4-tolyl)benzofuran thus formed as described in the procedure of Example 5.

Workup

  1. customthus formed

Sources & evidence

ORD record
ord-53fdcf57bb334061a2bcf6cc6a979e9a
Source dataset
uspto-grants-1976_03
Patent number
US03947470

Reaction notes

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