p-Anisoyl chloride → HCID 21435378, compound

HRID 268369Notes

Reaction equation

C1(C2C3C=CC=CC=3OC=2)C=CC=CC=1.C(Cl)(=O)C1C=CC(OC)=CC=1.C[O:28][C:29]1[CH:51]=[CH:50][C:32]([C:33]([C:35]2[O:36][C:37]3[CH:49]=[CH:48][CH:47]=[CH:46][C:38]=3[C:39]=2[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[O:34])=[CH:31][CH:30]=1>>[OH:28][C:29]1[CH:30]=[CH:31][C:32]([C:33]([C:35]2[O:36][C:37]3[CH:49]=[CH:48][CH:47]=[CH:46][C:38]=3[C:39]=2[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[O:34])=[CH:50][CH:51]=1

Participants

Reactant 3

HCID 7477p-Anisoyl chloride

HCID 6066153-Phenylbenzofuran

HCID 21435346HCID 21435346, compound

Product 1

HCID 21435378HCID 21435378, compound

Procedure

Acylation of 3-phenylbenzofuran with p-anisoyl chloride over a 4 hour period as described in the procedure of Example 1 followed by demethylation of the 2-(4-methoxybenzoyl)-3-phenylbenzofuran thus formed as previously described gives 2-(4-hydroxybenzoyl)-3-phenylbenzofuran.

Workup

customthus formed

Sources & evidence

ORD record: ord-5ffa943d50df4db4bcd9c781a2dea2b2
Source dataset: uspto-grants-1976_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03947470

Reaction notes

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